Dr. Amit Patwa
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Dr. Amit Patwa joined Navrachana University in October 2017 as an Assistant Professor. Prior to that, he worked as a post-doctoral research fellow in the laboratory of Prof. Mark W. Grinstaff at Boston University, Boston, USA. He was involved in synthesis, characterization and purification of i) contrast agent for sensitive and quantitative cartilage imaging, ii) polymer and polymeric hydrogel for biomedical applications, iii) PhotoresponsiveCrosslinker for light-induced cleavage and biomedical release application. As post-doctoral research fellow in the laboratory of Prof. Philippe Barthélémy at INSERM, France, he was involved in three different projects. His post-doctoral research work involve molecular recognition and the use of bio-inspired amphiphiles (e.g. Glycosylated Nucleoside Lipids (GNLs), Locked Nucleic Acid (LNA)-based nucleolipids, oligonucleotides-based nucleolipids, etc.) to create novel supramolecular assemblies for multiple applications ranging from molecular building blocks for self-assemblies, to nucleic acids imaging to drug or biomolecule delivery systems. During the course of his doctoral research (under the guidance of Prof. Krishna. N. Ganesh and Vaijayanti. A. Kumar at NCL), he was involved in the studies towards the design, synthesis and X-ray crystal structure studies of ferrocene-nucleobase conjugates.The results are interesting from the point of understanding and engineering supramolecular assemblies through rational design of base pairing patterns. Before his doctoral research, he was working as Project Assistant in polymer chemistry division. The objective of the project was to provide a narrow polydispersity polymer with photo initiation at room temperature and providing controlled/“living” radical polymerization utilizing visible light thereby avoiding the use of free radical initiator. During this period, experience in synthetic organic chemistry and photochemical polymerization using synthesized initiating system were gained. Immediate after his master’s degree, he was working in a company “Synth Services”- A custom manufacturer of specialty chemicals and drug intermediates. During this period, he gained experience in pure synthetic organic chemistry. During his tenure, he had an opportunity to work in a process development plant where he gained experience in high vacuum distillation and handling of hazardous chemicals on kilogram scale. With these experiences, he now describes himself as a synthetic organic chemist who is keen to understand the biochemical processes in the living organism with the knowledge of bio-organic chemistry.
Doctor of Philosophy (Ph. D.):National Chemical Laboratory, Pune, Maharashtra, India
Ph. D. Thesis Title: “DNA-Ferrocene Covalent Adducts for Studying DNA Conductance and EngineeringMolecular Recognition Switch of DNA Base Pairing” (Research Guide: Prof. Krishna. N. Ganesh; Research Co-Guide: Dr. Vaijayanti A. Kumar)
Master of Science (M. Sc.)-Organic Chemistry: The Maharaja Sayajirao University of Baroda, Vadodara, Gujarat, India
Bachelor of Science (B. Sc.)-Chemistry: The Maharaja Sayajirao University of Baroda, Vadodara, Gujarat, India
He gained extensive research experience (more than 14 years) in the field of synthetic organic chemistry, nucleic acid chemistry, molecular recognition and supramolecular chemistry, bio-organic chemistry. Over the years, his research approaches have been experiencing transformations from pure synthetic organic chemistry to bioorganic chemistry to nucleic acid chemistry. Understanding the momentousness of present research scenario, he developed a strong interest in interdisciplinary research that will provide scope for diversity of experimental and intellectual approaches that include: synthetic organic chemistry, bioorganic chemistry, molecular recognition and supramolecular chemistry. His basic research question has always been to develop a contrivance for better understanding of biochemical processes in the living organism to address questions of importance in biology and medicine. His involvement as research fellow at NCL and postdoctoral fellow at INSERM and Boston University has given him ample opportunities to interact with several scientists in India, France, UK and USA. This has immensely contributed to hi scientific development. In the near future, he would like to conduct an interdisciplinary research collaborating with these scientific partners in addition to new collaborators. His research vision calls for the development of a laboratory where synthesis and application of bio-inspired molecules will be the central theme. Research demands effective communication with the scientific community and stakeholders. Therefore, he looks forward to publishing his research-team’s work in high-impact journals.
Professor Amit Patwa teaches Organic Chemistry and related subjects to Science Post graduate and undergraduate students (MSc and BSc). His teaching philosophy can better be described as a philosophy of learning. Therefore, it is much effective in teaching the students how to learn, rather than giving mere facts. Learning through active interaction between an instructor and a student is a part of teaching. Thus, his goal is to ensure students have a better understanding of basic concepts, theories and practical knowledge so that they may apply this information to their future research or professional activities.
List of publications (International)
(Publications: 15, Total citation-222, h-index-08, i10-index-07)
- Stewart, R.C.; Patwa, A.N.; Lusic, H.;Freedman, J.D.; Wathier, M.; Snyder, B.D.; Guermazi, A.; Grinstaff, M.W. Synthesis and Pre-Clinical Characterization of a Cationic Iodinated Imaging Contrast Agent (CA4+) and Its Use for Quantitative Computed Tomography of Ex Vivo Human Hip Cartilage J. Med. Chem., 2017, 60 (13), 5543–5555.
- Patwa, A.; Thiéry, A.; Lombard, F.; Lilley, M. K. S.; Boisset, C.; Bramard, J.-F.; Bottero, J-Y.; Barthélémy, P. Accumulation of nanoparticles in "jellyfish" mucus: a bioinspired route to decontamination of nano-waste. Sci. Rep. 2015, 5, 11387; doi: 10.1038/srep11387.
- Patwa, A.; Labille, J.; Bottero, J-Y.; Thiéry, A.; Barthélémy, P. Decontamination of nanoparticles from aqueous samples using supramolecular gels. Chem. Commun. 2015, 51, 2547-2550.
- Gissot, A; Oumzil, K; Patwa, A.; Barthélémy, P.A hybrid lipid oligonucleotide: a versatile tool for supramolecular chemistry. New J. Chem. 2014, 38, 5129-5134. (Impact Factor: 3.269)
- Latxague, L.#; Patwa, A.#; Amigues, E.; Barthélémy, P. Glycosyl-Nucleolipids as New Bioinspired Amphiphiles. Molecules2013, 18, 12241–12263. (#) These authors contributed equally to this work.
- Patwa, A.; Salgado, G.; Dole, F.; Navailles, L.; Barthelemy, P. Tuning Molecular Interactions in Lipid-oligonucleotides Assemblies via Locked Nucleic Acid (LNA)-based Lipids. Org. Biomol. Chem.2013, 11, 7108-7112. (Graphics was selected as inside front cover of the same issue)
- Aimé, A.; Beztsinna, N.; Patwa, A.; Pokolenko, A.; Bestel, I.; Barthélémy, P. Quantum Dot Lipid Oligonucleotide Bioconjugates: Toward a New anti-microRNA Nanoplatform. Bioconjug. Chem.2013, 24, 1345–1355.
- Dolain, C.; Patwa, A.; Godeau, G.; Barthélémy, P. Nucleic Acid Based Fluorinated Derivatives: New Tools for Biomedical Applications. Appl. Sci.2012, 2, 245–259.
- Ziane, S.;Schlaubitz, S.; Miraux, S.; Patwa, A.; Lalande, C.; Bilem, I.; Lepreux, S.; Rousseau, B.; Le Meins, J.-F.; Latxague, L.; Barthélémy, P.; Chassande, O. A ThermosensitiveLowMolecularWeight Hydrogel as Scaffold for Tissue Engineering. Eur. Cell. Mater.2012, 23, 147–160.
- Latxague, L.; Dalila, M.-J.; Patwa, A.; Ziane, S.; Chassande, O.; Godeau, G.; Barthélémy, P. Glycoside Nucleoside Lipids (GNLs): An Intrusion into the Glycolipids’ World? ComptesRendusChim.2012, 15, 29–36.
- Latxague, L.; Ziane, S.; Chassande, O.; Patwa, A.; Dalila, M.-J.; Barthélémy, P. Glycosylated Nucleoside Lipid Promotes the Liposome Internalization in Stem Cells. Chem. Commun.2011, 47, 12598–12600. (Graphics was selected as back cover of the same issue)
- Patwa, A.; Gissot, A.; Bestel, I.; Barthélémy, P. Hybrid Lipid Oligonucleotide Conjugates: Synthesis, Self-assemblies and Biomedical Applications. Chem. Soc. Rev.2011, 40, 5844–5854.
- Patwa, A. N.; Gonnade, R. G.; Kumar, V. A.; Bhadbhade, M. M.; Ganesh, K. N. Ferrocene-bis(thymine/uracil) Conjugates: Base Pairing Directed, Spacer Dependent Self-assembly and Supramolecular Packing. J. Org. Chem.2010, 75, 8705–8708.
- Patwa, A. N.; Gupta, S.; Gonnade, R. G.; Kumar, V. A.; Bhadbhade, M. M.; Ganesh, K. N. Ferrocene-linked Thymine/uracil Conjugates: Base Pairing Directed Self-assembly and Supramolecular Packing. J. Org. Chem.2008, 73, 1508–1515.
- Patwa, A. N.; Tomer, N. S.; Singh, R. P. Visible Light-induced Controlled/“living” Radical Polymerization of Styrene. J. Mater. Sci.2004, 39, 1047–1049.
- Singh, R. P.; Patwa, A. N.; Desai, S. M.; Pandey, J. K.; Solanky, S. S.; Vishwa Prasad, A. Synthesis of New Polymeric Hindered Amine Light Stabilizers: Performance Evaluation in Styrenic Polymers. J. Appl. Polym. Sci.2003, 90, 1126–1138.
- Kern, A., Seitz, O., Patwa, A., Gissot, A., Oumzil, K., Barthélémy, P., Strazewski, P., Latorre, A. and Somoza, Á. (2014) Conjugation of DNA with Biomolecules and Nanoparticles, in DNA in Supramolecular Chemistry and Nanotechnology (eds E. Stulz and G. H. Clever), John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/9781118696880.ch4
Patent and EnveloppeSoleau
- Philippe Barthélémy, Alain Thiéry, Amit Patwa. Hydrogel-based decontamination of aqueous samples containing nanoparticles.US Patent App. 14/374,676, 2013.
- Patwa, A.; Thiéry, A. and Barthélémy, P. Nanoparticles decontamination by nanostructure gels (2011) Env. Soleau N˚ 412082, Institut National de la Propriété Industrielle (INPI). 03-2011
- Large-scale Synthesis and Pre-Clinical Characterization of a Cationic Iodinated Imaging Contrast Agent (CA4+) and Its Use for Quantitative Computed Tomography of Ex Vivo Human Hip Cartilage. “252nd American Chemical Society National Meeting and Exposition” held between 21st -25th August 2016 at Pennsylvania Convention Center, Philadelphia, PA, USA.
- Tuning molecular interactions in Lipid-Oligonucleotides assemblies via locked nucleic acid (LNA)-based lipids. “IVth International Symposium on SupraBiomolecular system (SupraBio IV-Next generation)” held on 13th and 14th June 2013 at Cassis, French Riviera, France.
- Glycoside nucleoside lipids (GNLs): An intrusion into the glycolipids’ world? “International Meeting on Chemical Biology (May 26-28, 2013)” held between 26th-28th May 2013 at Indian Institute of Science Education and Research (IISER), Pune, India.
- Synthesis, characterization and physico-chemical studies of Locked nucleic acid (LNA)-based lipids “XXVIth Scientific GTRV meeting” (GroupeThematique de Recherche sur la Vectorization-Thematic Research Group of the Vectorization) held between 5th-7th December 2011 at UniversitéCatholique de Louvain, Brussels, Belgium.
- Locked nucleic acid (LNA)-based lipids: Effect of the locked ribose conformation on their supramolecular assemblies. “Sixth Cambridge Symposium on Nucleic Acids Chemistry and Biology” held between 4th-7th September 2011 at Queens’ College, Cambridge, UK.
- Ferrocene linked thymine/uracil conjugates: Base pairing directed self-assembly and supramolecular packing. “US-India Nanoscience and Engineering Institute (USINSEI)” held between 9th and 18th January 2008 at MGM Beach Resorts, Chennai-India.
- Design, synthesis and characterization of Ferrocene linked thymine/uracil conjugates:Base pairing directed self-assembly and supramolecular packing“Asia Academic Seminar On Molecular, Supramolecular Materials with Designed Functions” held between 24th-28th February 2007 at National Chemical Laboratory, Pune (Maharashtra)-India.
- Synthesis and characterization of Ferrocene linked thymine/uracil conjugates and their supramolecular assemblies “Royal Society of Chemistry-West India Section Student Symposium 2006” held on 13th and 14th October 2006 at Department of Chemistry, Faculty of Science, The Maharaja Sayajirao University of Baroda, Vadodara (Gujarat)-India.
Fellowship / Awards
- Junior Research Fellowship(2003-2005) and Senior Research Fellowship (2005-2008), awarded by the University Grants Commission, India, on the basis of National Eligibility Test (NET).
- Lectureship Award (LS) awarded by “University Grants Commission of India-CSIR (UGC-CSIR)”, on the basis of National Eligibility Test (2002).
- Qualified in Graduate Aptitude Test in Engineering(GATE) 2003, with a percentile score of 96.19 (All India Rank – 110, Total candidates appeared - 2936).
- Recipient of Shri Madhavji Bhatt Prize and Dr. M. S. Patel Prize for securing the highest number of marks in first year B. Sc. (1996) and second year B. Sc. (1997)
- American Chemical Society (ACS) membership (2016-2017)