Prof. (Dr.) A. V. Ramachandran

Prof.(Dr.) A. V. Ramachandran

Mentor

SS

avramachandran@nuv.ac.in

Education

  • Ph.D.– Department of Zoology, Faculty of Science, The M. S. University of Baroda, Vadodara-390002, Gujarat, India.
  • M.Sc.– Department of Zoology, Faculty of Science, The M. S. University of Baroda, Vadodara-390002, Gujarat, India.
  • B.Sc.– Department of Zoology, Faculty of Science, The M. S. University of Baroda, Vadodara-390002, Gujarat, India.

Background

Prof. Ramachandran has 40 years of vast experience in teaching and research. His extensive teaching involvement covers various branches of Life Science like Cell Biology, Molecular Biology, Genetics, Microbial Genetics, Immunology, Developmental Biology, Biotechnology, Biostatistics, Reproduction Physiology and Endocrinology.

Research Areas and Contribution

Actively involved in research in the areas of Developmental Physiology, Metabolic and Reproductive endocrinology, Toxicology, Neonatal hormonal programming leading to developmental plasticity and adult thrifty phenotype, and Phytotherapy in relation to disorders like diabetes, hypercholesterolemia, Non-alcoholic steatohepatitis and Metaltoxicity.

Started pioneering work on reptilian regeneration in India and initiated studies on pineal modulation of metabolic functions and reproductive processes in the vertebrate series with emphasis on birds and mammals. initiated studies on neonatal hormonal disturbances in inducing developmental plasticity and role of melatonin as a deprogrammer.

A Brief Overview of Research and Development Activities

  • Started pioneering work on regeneration studies· with a reptilian model the only school working on regeneration in India and one of the very few working internationally. Have helped firmly establish the reptilian regeneration group in India.
  • Initiated studies on reproductive endocrinology of both birds and mammals. In the process, the department of Zoology, The M.S.University of Baroda became one of the few schools in India working on pineal influenced metabolic functions and reproductive activities. Especially, pineal-adrenal and pineal-thyroid interactions have been studied in detail in birds in controlling seasonal reproduction.
  • Another area explored was the development of adult thrifty phenotype with reference to reproductive functioning diabetic manifestations due to developmental plasticity induced by neonatal hormonal programming.
  1. International Society of Andrology Award for “Scientific Excellence” – Awarded at the VII ISA conference at Montreal, CANADA-2001.
  2. Awarded “Prof. Pera Naidu Govindarajulu Gold Medal” for Career Research in Reproduction and Endocrinology-1997.
  3. Conferred the “Fellowship inReproduction and Endocrinology(FRE)” of the National society for Reproductive Biology and Comparative Endocrinology- 1995.
  4. INSA visiting fellowship-1992.
  5. “Hari Ohm Ashram PreritBhaikaka Inter University Smarak Trust” award for the Best Research Paper for the year 199l.

Published more than 250 research articles and research papers in recognized peer-reviewed journals. The latest publications in past 10 years include:

2018

J04 – R Patel, N Rathwa, SP Palit,AV Ramachandran and R Begum, Association of melatonin & MTNR1B variants with type 2 diabetes in Gujarat population, Biomedicine & Pharmacotherapy 103, 429-434 (2018).

J03 – Rathwa, N., Patel, R., Palit, S. P., Ramachandran, A. V., & Begum, R., Genetic variants of resistin and its plasma levels: Association with obesity and dyslipidemia related to type 2 diabetes susceptibility. Genomics, (2018).

J02 – Patel, R., Palit, S. P., Rathwa, N., Ramachandran, A. V., & Begum, R., Genetic variants of tumor necrosis factor-α and its levels: A correlation with dyslipidemia and type 2 diabetes susceptibility. Clinical Nutrition, (2018).

J01 – Pramanik, S., Rathwa, N., Patel, R., Ramachandran, A. V., & Begum, R., Treatment Avenues for Type 2 Diabetes and Current Perspectives on Adipokines. Current diabetes reviews, 14(3), 201-221, (2018).

2017

J01 – Banerjee, S., Joshi, N., Mukherjee, R., Singh, P. K., Baxi, D., &Ramachandran, A. V., Melatonin protects against chromium (VI) induced hepatic oxidative stress and toxicity: Duration dependent study with realistic dosage. Interdisciplinary Toxicology, 10(1), 20-29, (2017).

2016

J01 – Patel, R., Dwivedi, M., Mansuri, M. S., Laddha, N. C., Thakker, A., Ramachandran, A. V., & Begum, R., Association of neuropeptide-Y (NPY) and interleukin-1beta (IL1B), genotype-phenotype correlation and plasma lipids with Type-II diabetes. PloS one, 11(10), e0164437, (2016).

2015

J01 – Gajaria, T. K., Patel, D. K., Devkar, R. V., &Ramachandran, A. V., Flavonoid rich extract of MurrayaKoenigii alleviates in-vitro LDL oxidation and oxidized LDL induced apoptosis in raw 264.7 Murine macrophage cells. Journal of food science and technology, 52(6), 3367-3375, (2015).

2014

J02 – Ravirajsinh Jadeja Ranjitsinh V. Devkar and Srinivas Nammi. Herbal Medicines for the Treatment of Nonalcoholic Steatohepatitis: Current Scenario and Future Prospects. Evidence-Based Complementary and Alternative Medicine, Article ID 648308, 2014, I.F. 2.175 http://dx.doi.org/10.1155/2014/648308

J01 – Tejal K. Gajaria, Dipak K. Patel, Ranjitsinh V. Devkar, A. V. Ramachandran. Flavonoid rich extract of Murrayakoenigii alleviates in-vitro LDL oxidation and ox-LDL induced apoptosis in RAW 264.7 murine macrophage cells. Journal of food Science and Technology, 2014, I.F. 2.023, DOI. 10.1007/s13197-014-1399-2.

2013

J02 – Patel D, Desai S, Gajaria T, Devkar R, Ramachandran AV. Coriandrum sativum L. seed extract mitigates lipotoxicity in RAW 264.7 cells and prevents atherogenic changes in rats. EXCLI Journal. 2013,12:313-334.

J01 – Jadeja RN, Devkar RV. Polyphenols and Flavonoids in Controlling Non-Alcoholic Steatohepatitis. In: Polyphenols in Human Health and Disease, Ronald Ross Watson, Victor R. Preedy and ShermaZibadi, San Diego, 2014, Pages 615–623. [Book Chapter]

2012

J11 – Patel D, Desai S, Devkar R, Ramachandran A.V. Acute and sub-chronic toxicological evaluation of hydro-methanolic extract of Coriandrumsativum L. seeds. EXCLI Journal 2012;11:556-575. [IF: 1.06]

J10 – Patel DK, Desai SN, Gandhi HP, Devkar RV, Ramachandran AV. Cardio protective effect of Coriandrumsativum L. on isoproterenol induced myocardial necrosis in rats. Food and Chemical Toxicology. 2012, 50: 3120-3125. [IF: 2.99]

J09 – Thounaojam MC, Jadeja RN, Salunke SP, Devkar RV, Ramachandran AV. Sidarhomboidea. Roxb aqueous extract down-regulates in vivo expression of vascular cell adhesion molecules in atherogenic rats and inhibits in vitro macrophage differentiation and foam cell formation. Immunopharmacology and Immunotoxicology, 2012, 34: 832-843. [IF:1.829]

J08 – SankhariJM,  Jadeja RN, Thounaojam MC, Devkar RV, Ramachandran AV. Eugenia jambolana seed extract supplementation attenuates cardiac and hepatic oxidative stress and pathophysiological changes in hypercholesterolemic rats. Oriental Pharmacy and Experimental Medicine. 2012; 12:99-106. [Springer]

J07 – Sankhari JM, Thounaojam MC, Jadeja RN, Devkar RV, Ramachandran AV. Anthocyanin-rich red cabbage (Brassica oleracea L.) extract attenuates cardiac and hepatic oxidative stress in rats fed an atherogenic diet. Journal of the Science of Food Agriculture. 2012; 92: 1688-93.  [IF:1.436]

J06 – Jadeja RN, Thounaojam MC, Singh TB, Devkar RV, Ramachandran A.V. Traditional uses, phytochemistry and pharmacology of ClerodendronglandulosumColeb – a review. Asian Pacific Journal of Tropical Medicine. 2012; 5(1):1-6. [IF:0.371]

J05 – Desai SN, Patel DK, Devkar RV, Patel PV, Ramachandran AV. Hepatoprotective potential of polyphenol rich extract of Murrayakoenigii L.: An in vivo study. Food and Chemical Toxicology. 2012; 50: 310–314. [IF:2.99] {Cited by: 1}

J04 – Thounaojam MC, Jadeja RN, Devkar RV, Ramachandran AV. Non-alcoholic steatohepatitis: an overview including treatments with herbals as alternative therapeutics. Journal of applied Biomedicine, 2012; 10; 119-136. [IF:1.933]

J03 – Jadeja RN, Thounaojam MC, Jain M, Devkar RV, Ramachandran AV. Clerodendronglandulosum.Coleb leaf extract attenuates in vitro macrophage differentiation and expression of VCAM-1 and P-selectin in thoracic aorta of atherogenic diet fed rats. Immunopharmacology and Immunotoxicology, 2011; 34:443-53. [IF: 1.829]

J02 – Jadeja RN, Thounaojam MC, Sankhari JM, Jain M, Devkar RV, Ramachandran AV. Standardized Flavonoid-Rich Eugenia jambolana Seed Extract Retards In Vitro and In Vivo LDL Oxidation and Expression of VCAM-1 and P-Selectin in Atherogenic Rats. Cardiovascular Toxicology, 2012; 12: 73-82. [IF: 2.015]

J01 – Thounaojam MC, Jadeja RN, Devkar RV, Ramachandran AV. Sidarhomboidea.Roxb extract alleviates pathophysiological changes in experimental in vivo and in vitro models of high fat diet/fatty acid induced non alcoholicsteatohepatitis. Experimental and Toxicologic Pathology, 2012; 64; 217-24. [IF:2.7] {Cited by: 2}  Web: http://www.ncbi.nlm.nih.gov/pubmed/20832268

2011

J08 – Thounaojam MC, Jadeja RN, Ramani UV, Devkar RV, Ramachandran AV. Sidarhomboidea.Roxb leaf extract down-regulates expression of PPARγ2 and leptin genes in high fat diet fed C57BL/6J mice and retards in vitro 3T3L1 pre-adipocyte differentiation. International Journal of Molecular Science, 2011; 12(7): 4661–4677. [IF:2.22] {Cited by: 1} Web:http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3155376/

J07 – Thounaojam MC, Jadeja RN, Devkar RV, Ramachandran AV. In Vitro evidence for the protective role of Sidarhomboidea. Roxb extract against LDL oxidation and oxidized LDL induced Apoptosis in human monocyte derived macrophages. Cardiovascular Toxicology, 2011; 11:168-179. [IF: 1.80] {Cited by: 4} Web: http://www.ncbi.nlm.nih.gov/pubmed/21384160

J06 – Thounaojam MC, Jadeja RN, Sankhari JM, Devkar RV, Ramachandran AV. Safety Evaluations on Ethanolic Extract of Red Cabbage (Brassica oleracea L.) in Mice. Journal of Food Science, 2011; 76: T35–T39. [IF:1.70] {Cited by: 2} Web:http://www.ncbi.nlm.nih.gov/pubmed/21535729

J05 – Thounaojam MC, Jadeja RN, Ansarullah, Karn SS, Shah JD, Patel DK, Salunke SP, Padate GS, Devkar RV, Ramachandran AV. Cardioprotective effect of Sidarhomboida. Roxb extract against isoproterenol induced myocardial necrosis in rats. Experimental and Toxicologic Pathology, 2011; 63:351-356. [IF: 2.22] {Cited by: 4}

J04 – Patel DK, Desai SN, Devkar RV, Ramachandran AV. Coriandrumsativum L. aqueous extract mitigates high fat diet induced insulin resistance by controlling visceral adiposity in C57BL/6J Mice. BolLatinoam Caribe Plant Med Aromat, 2011; 10(2): 127 – 135. [IF: 0.37]

J03 – Jadeja RN, Thounaojam MC, Ramani UV, Devkar RV, Ramachandran AV. Anti-obesity potential of Clerodendronglandulosum. Colebleaf  aqueous extract. Journal of Ethnopharmacology, 2011; 135:338-343. [IF: 2.43] {Cited by: 3} http://www.ncbi.nlm.nih.gov/pubmed/21397678

J02 – Jadeja RN, Thounaojam MC, Devkar RV, Ramachandran AV. Clerodendronglandulosum.Coleb extract prevents in vitro human LDL  oxidation and oxidized LDL induced Apoptosis in human monocyte derived macrophages. Food and Chemical Toxicology, 2011; 49:1195-1202. [IF: 2.60]  {Cited by: 7} Web: http://www.ncbi.nlm.nih.gov/pubmed/21371519

J01 – Jadeja RN, Thounaojam MC, Ansarullah, Jadav SV, Patel MD, Patel DK, Salunke SP, Padate GS, Devkar RV, Ramachandran A V. Toxicological evaluation and hepatoprotective potential of ClerodendronglandulosumColeb leaf extract. Human and Experimental Toxicology, 2011; 30(1):63-70. [IF: 1.32] {Cited by: 4} Web:http://het.sagepub.com/content/early/2010/04/12/0960327110368420

2010

J09 – Thounaojam MC, Jadeja RN, Devkar RV, Ramachandran AV. Sidarhomboidea. Roxb leaf extract ameliorates gentamicin induced nephrotoxicity and renal dysfunction in rats Journal of Ethnopharmacology, 2010; 132:365-367. [IF:2.43] {Cited by: 8}

J08 – Thounaojam MC, Jadeja RN, Devkar RV, Ramachandran AV. Antioxidant and free radical scavenging activity of SidarhomboideaRoxb. methanolic extract determined using different in vitro models. BoletinLatinoamericano y del Caribe de PlantasMedicinales y Aromaticas, 2010; 9, 191-198. [IF:0.37] {Cited by: 5} Web: http://www.revistas.usach.cl/ojs/index.php/blacpma/article/view/152

J07 – Thounaojam MC, Jadeja RN, Ansarullah, Devkar RV, Ramachandran AV .Prevention of high fat diet induced insulin resistance in C57/BL/6J mice by SidarhomboideaRoxb. extract. Journal of Health Science, 2010; 56, 92-98. [IF: 0.68] {Cited by: 7} Web:http://www.jstage.jst.go.jp/article/jhs/56/1/56_92/_article

J06 – Thounaojam MC, Jadeja RN, Patel DK, Devkar RV, Ramchandran AV. Acute and subchronic oral toxicity of SidarhomboideaRoxb. Leaf extract. Journal of Complementary and Integrative Medicine, 2010; 7(1) 1. [PubMed] {Cited by: 5}

J05 – Jadeja RN, Thounaojam MC, Ansarullah, Devkar RV, Ramchandran AV. ClerodendronglandulosumColeb. Verbenaceae, ameliorates high fat diet-induced alteration in lipid and cholesterol metabolism in rats. RevistaBrasileira de Pharmacognosia, 2010; 20(1): 117-123. [IF: 3.46]  {Cited by: 8} Web: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2010000100023

J04 – Jadeja RN, Thounaojam MC, Patel DK, Devkar RV, Ramachandran AV.  Pomegranate (Punicagranatum L.) juice supplementation attenuates isoproterenol induced cardiac necrosis in rats. Cardiovascular toxicology, 2010; 10(3):174-80. [IF: 2.56] {Cited by: 7} Web: http://www.ncbi.nlm.nih.gov/pubmed/20509006

J03 –  Jadeja RN, Thounaojam MC, Ansarullah, Patel VB, Devkar RV, Ramachandran AV. Protective effect of Clerodendronglandulosum extract against experimentally induced metabolic syndrome in rats. Pharmaceutical Biology, 2010; 48(12):1312-1319 [IF: 0.672] {Cited by: 3} Web: http://www.ncbi.nlm.nih.gov/pubmed/20843167

J02 – Jadeja RN, Thounaojam MC, Dandekar DS, Devkar RV, Ramachandran AV.  Clerodendronglandulosum.Coleb extract ameliorates high fat diet/fatty acid induced lipotoxicity in experimental models of non alcoholicsteatohepatitis. Food and Chemical Toxicology, 2010; 48 (12): 3424-3431. [IF:2.11] {Cited by: 7} http://www.ncbi.nlm.nih.gov/pubmed/20849909

J01 – Sankhari JM, Jadeja RN, Thounaojam MC, Devkar RV, Ramachandran AV. Safety evaluation of Eugenia jambolana seed extract. Asian Pacific Journal of Tropical Medicine. 2010; 12: 982-987. [IF:0.17] {Cited by: 3} http://www.sciencedirect.com/science/article/pii/S199576451160014X

2009

J05 – Thounaojam MC, Jadeja RN, Ansarullah, DevkarRV,Ramachandran AV. Potential of Sidarhomboidea.roxb Leaf Extract in Controlling Hypertriglyceridemia in Experimental Models. Pharmacognosy Research 2009; 1: 208-212. [PubMed] {Cited by: 8} http://www.phcogres.com/article.asp?issn=0974-8490;year=2009;volume=1;issue=4;spage=208;epage=212;aulast=Thounaojam

J04 – Thounaojam M, Jadeja R, Ansarullah, Devkar R, Ramachandran AV. Dysregulation of lipid and cholesterol metabolism in high fat diet fed hyperlipidemic rats: Protective effect of Sidarhomboidea.roxb leaf extract. J  Health Sci 2009; 55:413-420. [IF: 0.65] {Cited by: 22} http://jhs.pharm.or.jp/data/55(3)/55_413.pdf

J03 –  Jadeja R, Thounaojam M, nsarullah, Ramchandran AV, Devkar R. Phytochemical constituents and free radical scavenging activity of ClerodendronglandulosumColebmethanolic extract. Journal of complementary and Integrative medicine, 2009; 6(19): 1-23. [PubMed] {Cited by: 11}  http://www.bepress.com/jcim/vol6/iss1/19/

J02 – Jadeja, RN Thounaojam MC, Ansarullah, Devkar RV, Ramchandran AV. A prelimnary study on hypolipidemic effect of aqueous extract of Clerodendronglandulosum. Coleb.  International Journal of Green Pharmacy, 2009; 2(4): 119-123. [Scopus] {Cited by: 7} http://www.greenpharmacy.info/article.asp?issn=0973-8258;year=2009;volume=3;issue=4;spage=285;epage=289;aulast=Jadeja

J01 –  Patel DK, Patel KA, Patel UK, Thounaojam MC, Jadeja RN, Ansarullah, Padate GS, Salunke SP, Devkar RV, Ramachandran AV. Assessment of lipid lowering effect of Sidarhomboidea.Roxbmethanolic extract in experimentally induced hyperlipidemia. Journal of Young Pharmacists, 2009; 1:233-238. [PubMed]  {Cited by: 7} http://www.jyoungpharm.in/article.asp?issn=0975-1483;year=2009;volume=1;issue=3;spage=233;epage=238;aulast=Patel

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