Assistant Professor
Dr. Gaurav Parashar
ScienceGenetics and Epigenetics, Molecular Oncology, Aptamer based theranostics
Member
- Member, The Epigenetics Society
- Member, The International Society of Aptamers
- Member, European Association for Cancer Research (EACR) from 2019-2023
- Ex-Member, Institutional Biosafety Committee (IBSC), MMDU, Mullana
Teaching and accomplishments
His current focus is to develop DNA methylation based epigenetic biomarkers using circulatory biomolecules obtained from liquid biopsies in different pathological conditions such as cancer, cardiac and neurodegenerative disorders. He has completed his PhD from Panjab University, Chandigarh in 2015 with fellowship support from CSIR and has worked on identifying the potential of natural compounds in reversal of promoter hypermethylation induced gene silencing of tumor suppressor genes. He was awarded DST-NPDF in 2016 to conduct research at NIPER, Mohali on developing and characterizing RNA aptamer with expression specific cellular internalization, targeted against human cytidine deaminase protein. Further to his completion of DST-NPDF tenure, Dr. Parashar was awarded with DHR-ICMR Young Scientist in 2019 with a funding support to conduct research on identifying the role of N6AMT1 protein as an adenine methyltransferase and maintenance of DNA methylation. Moreover, he also developed a restriction enzyme associated qPCR-based assay to determine locus/promoter-based DNA adenine methylation which was subsequently patented and further research is ongoing to establish the assay clinically.
He has worked as an Assistant Professor at Dept. Biotechnology, Maharishi Markandeshwar (Deemed to be) University, Mullana for four years from 2018 till 2022. Apart from academic responsibilities, he was also responsible for research and maintenance requirement of the department. He was also involved in establishment and maintenance of the animal cell culture facility and central instrumentation facility of the University. Presently, he is working as an Assistant Professor at the Division of Biomedical and Life Sciences from January 2023. Explore the academic profile of Dr. Gaurav Parashar, a distinguished assistant professor at Navrachana University, India
Most notable publications
· Kumar A, Sharma B, Sharma U, Parashar G, Parashar NC, Rani I, Ramniwas S, Kaur S, Haque S, Tuli HS. Apoptotic and antimetastatic effect of cucurbitacins in cancer: recent trends and advancement. Naunyn Schmiedebergs Arch Pharmacol. 2023 Apr 3. doi: 10.1007/s00210-023-02471-z.
· Prasad R, Panchal S, Rani I, Kishan J, Parashar G. Identification of h-TERT Promoter Mutations in Germline DNA from North Indian Lung Carcinoma Patients. Ind J Clin Biochem. 2023; 38:120-127.
· Tuli HS, Sak K, Garg VK, Kumar A, Adhikary S, Kaur G, Parashar NC, Parashar G, Mukherjee TK, Sharma U, Jain A, Mohapatra RK, Dhama K, Kumar M, Singh T. Ampelopsin targets in cellular processes of cancer: Recent trends and advances. Toxicol Rep. 2022; 27 (9):1614-1623.
· Tuli HS, Sak K, Adhikary S, Kaur G, Aggarwal D, Kaur J, Kumar M, Parashar NC, Parashar G, Sharma U, Jain A. Galangin: A metabolite that suppresses anti-neoplastic activities through modulation of oncogenic targets. Exp Biol Med (Maywood). 2022; 247(4):345-359.
· Tuli HS, Aggarwal V, Parashar G, Aggarwal D, Parashar NC, Tuorkey MJ, Varol M, Sak K, Kumar M, Buttar HS. Xanthohumol: A Metabolite with Promising Anti-Neoplastic Potential. Anticancer Agents Med Chem. 2022; 22(3):418-432.
· Prasad R, Panchal S, Rani I, Parashar G, Kishan J, Bhatnagar M. Atypical Case of Highly Mutated h- TERT Promoter in Germline Genome from Buccal Mucosa Cancer. Ind J Clin Biochem.. 2021: 1-5.
· Bhatia R, Chakrabarti SS, Kaur U, Parashar G, Banerjee A, Rawal RK. Multi-Target Directed Ligands (MTDLs): Promising Coumarin Hybrids for Alzheimer’s Disease. Curr Alzheimer Res. 2021;18(10):802- 830.
· Aggarwal V, Tuli HS, Varol M, Tuorkey M, Sak K, Pa rashar NC, Barwal TS, Sharma U, Iqubal A, Parashar G, Jain A. NOTCH signaling: Journey of an evolutionarily conserved pathway in driving tumor progression and its modulation as a therapeutic target. Crit Rev Oncol Hematol. 2021;164:103403.
· Tuli HS, Mittal S, Aggarwal D, Parashar G, Parashar NC, Upadhyay SK, Barwal TS, Jain A, Kaur G, Savla R, Sak K, Kumar M, Varo l M, Iqubal A, Sharma AK. Path of Silibin in from diet to medicine: A dietary polyphenolic flavonoid having potential anti-cancer therapeutic significance. Semin Cancer Biol. 2020; 73: 196-218.
· Parashar NC, Parashar G, Nayyar H, Sandhir R. Differential DNA methylation in regulation of deacetylvindoline-4-O-acetyl transferase (DAT) gene in Catharanthus roseus. J. Plant Biochem. Biotechnol. 2020; 30 (2): 326-335.
· Parashar NC, Poddar J, Chakrabarti S, Parashar G. Repurposing of SARS-Co V nucleocapsid protein specific nuclease resistant RNA aptamer for therapeutics against SARS-Co V-2. Infect Genet Evol. 2020:104497.
· Tuli HS, Aggarwal V, Kaur J, Aggarwal D, Parashar G, Parashar NC, Tuorkey M, Kaur G, Savla R, Sak K, Kumar M. Baicalein: A metabolite with promising antineoplastic activity. Life Sci. 2020 8:118183.
· Chakrabarti SS, Kaur U, Banerjee A, Ganguly U, Banerjee T, Saha S, Parashar G, Prasad S, Chakrabarti S, Mittal A, Agrawal BK, Rawal RK, Zhao RC, Gambhir IS, Khanna R, Shetty AK, Jin K, Chakrabarti S. COVID-19 in India: Are Biological and Environmental Factors Helping to Stem the Incidence and Severity? Aging Dis. 2020; 11(3):480-488.
· Aggarwal V, Tuli HS, Kaur J, Aggarwal D, Parashar G, Chaturvedi Parashar N, Kulkarni S, Kaur G, Sak K, Kumar M, Ahn KS. Garcinol Exh ibits Anti-Neoplastic Effects by Targeting Diverse Oncogenic Factors in Tumor Cells. Biomedicines. 2020; 8(5):103.
· Parashar NC, Parashar G, Nayyar H, Sandhir R. N6-adenine DNA methylation demystified in eukaryotic genome: From biology to pathology. Biochimie. 2018; 144:56-62.
· Parashar G, Parashar NCh, Capalash N. – (-) Menthol Induces Reversal of Promoter Hypermethylation and Associated Up-Regulation of the FANCF Gene in the SiHa Cell Line. Asian Pac J Cancer Pre v. 2017; 18(5):1365-1370.
· Parashar G, Capalash N. Promoter methylation-independent reactivation of PAX1 by curcumin and resveratrol is mediated by UHRF1. Clin Exp Med. 2016; 16(3):471-8.
· Shukla AK, Mall M, Rai SK, Singh S, Nair P, Parashar G, Shasany AK, Singh SC, Joshi VK, Khanuja SP. A transcriptomic approach for e xploring the molecular basis for dosha-balancing property-based classification of plants in Ayurveda. Mol Biol Rep. 2013; 40(4):3255-62.
· Parashar G, Capalash N. Exp ression of the TIMP2 gene is not regulated by promoter hypermethylation in the Caski cell line. Oncol Lett. 2012; 3(5):1079-1082.
· Parashar G, Parashar NC, Capalash N. Curcumin causes promoter hypomethylation and increased e xpression of FANCF gene in SiHa cell line. Mol Cell Biochem. 2012; 365(1-2):29-35.
· Jha AK, Nikbakht M, Parashar G, Shrivastava A, Capalash N, Kaur J. Reversal of hypermethylation and reactivation of the RARβ2 gene by natural compounds in cervical cancer cell lines. Folia Biol (Praha). 2010; 56(5):195-200.
Patent
1. N-6 methyl adenine dependent and, sensitive restriction enzymes based QPCR assay for determining promoter/locus specific DNA adenine methylation. Application number: 202211001764. Filing Date: 12/ 01/ 2022. Published date: 21/01/2022.
2. Single stranded nucleic acid aptamers developed against Yersinia enterocolitica and methods thereof. Application number: 202011027958. Filing date: 01/07/2020. Published date: 07/ 01/ 2022
Awards and Recognition
· Awarded DHR-ICMR Young Scientist in June 2019
· Awarded DST-NPDF in March 2016
· Awarded CSIR-SRF and ICMR-SRF (Not availed) in June 2012
· Awarded CSIR-UGC (NET-LS) in June 2007, June 2009 and December 2009
